ACE inhibitors.

Captopril - hypertension/diabetes

12.5 mg, white scored capsule- shaped tablet marked ACE and 12.5; 25 mg, 50 mg white scored tablets marked ACE and tablet strength.

Tablets, captopril 12.5mg , 25mg , 50mg .

Mild to moderate hypertension. Severe hypertension where standard therapy is ineffective or inappropriate. Diabetic nephropathy in insulin dependent diabetes.

Mild to moderate hypertension
 Initially 12 .5 mg twice daily. Maintenance, 25 mg twice daily increasing gradually at 2 - 4 week intervals if necessary to maximum 50 mg twice daily.

Severe hypertension
Initially 12.5 mg twice daily increasing if necessary to maximum 50 mg three times daily. Diabetic nephropathy, 75 - 100 mg daily in divided doses.

Contact manufacturer.

• Obstruction
• Pregnancy
• lactation.

Renovascular hypertension
severe congestive heart failure. Haemodialysis.

Renal impairment
monitor renal function, white cell count and urinary protein before and during therapy.

Collagen vascular disease
Anaesthesia. Elderly.

• K+-sparing diuretics or K+ supplements
•  NSAIDs
•  vasodilators
•  clonidine
•  allopurinol
•  procainamide
•  probenecid
•  immunosuppressants
•  lithium
•  antidiabetic agents
• neuroleptics
•  tricyclic antidepressants
• antihypertensives.

• Neutropenia
• Agranulocytosis
• Thrombocytopenia
• Anaemia
• Proteinuria
• Hypotension
• Angioedema
• Rash
• Loss of taste
• Pancreatitis
• Tachycardia
• Gastric irritation
• Cough (rare).

Bristol-Myers Squibb / Ashbourne

(POM)