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Drug Details
DDAVP
Drug class Description :

Vasopressin analogues.

Generic Name :

Desmopressin acetate - endocrine

Drug description :

DDAVP/Desmopressin Intranasal Solution: intranasal solution. DDAVP Tablets: white scored tablets marked with strength. DDAVP/Desmopressin Injection: ampoules.

Presentation :

DDAVP/Desmopressin Intranasal Solution: Desmopressin acetate 100 micrograms/mL. DDAVP Tablets: Desmopressin acetate 0.1 mg , 0.2 mg . DDAVP/Desmopressin Injection: Desmopressin acetate 4 micrograms/mL.

Indications :

DDAVP/Desmopressin Intranasal Solution: Diagnosis and treatment of vasopressin-sensitive cranial diabetes insipidus; establishing renal concentration capacity. DDAVP Tablets: Treatment of vasopressin-sensitive cranial diabetes insipidus; treatment of post-hypophysectomy polyuria/ polydipsia. DDAVP/Desmopressin Injection: Cranial diabetes insipidus.

Adult Dosage :

DDAVP/Desmopressin Intranasal Solution: Diabetes insipidus treatment, 0.1 - 0.2 mL once or twice daily. Diabetes insipidus diagnosis, 0.2 mL as single dose. Limit fluid intake to maximum 0.5 litres from 1 hour before to 8 hours after administration.

Renal function testing, 0.4 mL. DDAVP Tablets: Diabetes insipidus, initially 0.1 mg three times daily. Maintenance 0.1 - 0.2 mg three times daily. Post-hypophysectomy polyuria/ polydipsia, titrate dose according to urine osmolality.

DDAVP/Desmopressin Injection: 1 - 4 micrograms intramuscularly, subcutaneously or intravenously

Child Dosage :

DDAVP/Desmopressin Intranasal Solution: Diabetes insipidus treatment, 0.05 - 0.2 mL daily, infants may require a lower dose. Diabetes insipidus diagnosis, 0.2 mL as single dose. Limit fluid intake to maximum 0.5 litres from 1 hour before to 8 hours after administration. Renal function testing, up to 1 year, 0.1 mL; 1 - 15 years, 0.2 mL. DDAVP Tablets: Diabetes insipidus, initially 0.1 mg three times daily. Maintenance 0.1 - 0.2 mg three times daily. Post-hypophysectomy polyuria/ polydipsia, titrate dose according to urine osmolality. DDAVP/Desmopressin Injection: Doses from 0.4 micrograms (0.1mL) may be used.

Contra Indications :

Cardiac insufficiency, hypertension.

Special Precautions :

Exclude psychogenic polydipsia and alcohol abuse before initiating therapy. Renal impairment, cardiovascular disease, electrolyte imbalance, cystic fibrosis. Pregnancy. Avoid fluid overload.

Interactions :

Indometacin (indomethacin), tricyclic antidepressants, chlorpromazine, carbamazepine.

Adverse Reactions :

Headache, stomach pain, nausea. Hyponatraemic convulsions.

Manufacturer :

Ferring

Drug Availability :

(POM)

Related Drugs - Vasopressin analogues
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